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March 2022, Vol 3, No 1
Erdafitinib in Asian Patients with Advanced CCA and FGFR Alterations: Updated Analysis
ASCO GI Highlights
March 2022, Vol 3, No 1
The ongoing open-label, multicenter, phase 2a LUC2001 study is investigating the efficacy and safety of the
FGFR
inhibitor erdafitinib in a molecularly defined subset of Asian patients with advanced cholangiocarcinoma (CCA) harboring
FGFR
alterations whose disease progressed after ≥1 previous systemic therapies.
Read More
Sitravatinib plus Tislelizumab for Advanced Biliary Tract Cancer in Patients Whose Disease Did Not Respond to at Least 1 Systemic Therapy
ASCO GI Highlights
March 2022, Vol 3, No 1
Given that monotherapy with immune checkpoint inhibitors, including the PD-1 inhibitor tislelizumab, has a modest effect in advanced biliary tract cancers, several combination strategies to improve the antitumor activity of immune checkpoint inhibitors are being explored.
Read More
Systemic Modified FOLFIRINOX Followed by Concurrent Floxuridine and Systemic Modified FOLFIRI in Patients with Unresectable CCA: The HELIX-ICC Study
ASCO GI Highlights
March 2022, Vol 3, No 1
The majority of patients with intrahepatic cholangiocarcinoma (CCA) present with advanced liver disease and are not candidates for curative resection. The current standard of care for patients with unresectable intrahepatic CCA is palliative chemotherapy with gemcitabine plus cisplatin.
Read More
Tucatinib plus Trastuzumab in Patients with Biliary Tract Cancer and HER2 Expression: Phase 2 Basket Study
ASCO GI Highlights
March 2022, Vol 3, No 1
Biliary tract cancers have dismal prognosis, and the treatment options are limited. Up to 15% of patients with biliary tract cancer have
HER2
-positive disease. Tucatinib is a highly selective
HER2
-directed tyrosine kinase inhibitor.
Read More
Quality-of-Life Trends Associated with Ivosidenib in Patients with CCA and IDH1 Mutation in the ClarIDHy Study
ASCO GI Highlights
March 2022, Vol 3, No 1
Ivosidenib is a first-in-class inhibitor of IDH1 mutation that is indicated for the treatment of previously treated, locally advanced or metastatic cholangiocarcinoma (CCA) and IDH1 mutation. This indication was approved based on the results of the phase 3 ClarIDHy clinical trial, which demonstrated significant improvement in progression-free survival with ivosidenib compared with placebo in patients with previously treated, unresectable or metastatic CCA harboring IDH1 mutations.
Read More
Pembrolizumab plus Granulocyte Macrophage Colony-Stimulating Factor in Patients with Advanced Biliary Tract Cancer
ASCO GI Highlights
March 2022, Vol 3, No 1
Immune checkpoint inhibitors used as monotherapy have demonstrated only modest activity in unselected patients with advanced biliary tract cancers, highlighting the need for novel strategies to improve patient outcomes. Granulocyte macrophage colony-stimulating factors (GM-CSF) show immunomodulatory effects and may therefore potentiate the activity of immune checkpoint inhibitors.
Read More
Varlitinib plus Gemcitabine and Cisplatin for First-Line Therapy in Patients with Advanced Biliary Tract Cancers
ASCO GI Highlights
March 2022, Vol 3, No 1
The current standard of care for the first-line treatment of patients with advanced biliary tract cancer is chemotherapy combination of gemcitabine plus cisplatin; however, this regimen yields only modest responses, underscoring the need for novel, more active treatments. Human epidermal growth factor receptor (HER) tyrosine kinases are often overexpressed in patients with biliary tract cancers.
Read More
Second-Line Chemoimmunotherapy in Patients with Advanced Biliary Tract Cancers: The BilT-03 Study
ASCO GI Highlights
March 2022, Vol 3, No 1
The multicenter, single-arm, phase 1b/2 BilT-03 study evaluated the benefit of a chemoimmunotherapy regimen that combines the 3-drug chemotherapy regimen of liposomal irinotecan, 5-fluorouracil (5-FU), and leucovorin, plus the PD-1 monoclonal antibody nivolumab, as second-line therapy in patients with advanced biliary tract cancers. The results were presented by Vaibhav Sahai, MBBS, MS, University of Michigan, Ann Arbor, at the 2022 ASCO GI Cancers Symposium.
Read More
Central Hepatobiliary Adverse Events in Patients with Liver Malignancies Undergoing Stereotactic Body Radiotherapy
ASCO GI Highlights
March 2022, Vol 3, No 1
Stereotactic body radiotherapy (SBRT) is increasingly being used for the treatment of patients with primary or metastatic liver cancer. A single-institution study was conducted to assess the incidence of central hepatobiliary adverse events (AEs) in patients with liver malignancies who were treated with SBRT, and to evaluate the relation with planned dosimetry to define predictors to minimize AEs. The results were presented by Nitika Thawani, Dignity Health Cancer Institute, Phoenix, AZ, at the 2022 ASCO GI Cancers Symposium.
Read More
Characterizing the Epidemiology of Biliary Tract Cancers in Spanish Patients in the RETUD Registry
ASCO GI Highlights
March 2022, Vol 3, No 1
Biliary tract cancers represent a heterogeneous group of tumors that includes intrahepatic cholangiocarcinoma (CCA), extrahepatic CCA, and gallbladder carcinoma. Teresa Macarulla, MD, PhD, Hospital Universitario Vall d’Hebron, Barcelona, Spain, and colleagues conducted a study to characterize the epidemiology of patients with biliary tract cancer, including patient management and survival outcomes. Dr Macarulla presented the results at the 2022 ASCO GI Cancers Symposium.
Read More
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