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March 2022, Vol 3, No 1
Financial Toxicity in Patients with Cholangiocarcinoma
ASCO GI Highlights
March 2022, Vol 3, No 1
Data related to health-related quality of life (QOL), including financial toxicity, for patients with cholangiocarcinoma (CCA) who are receiving targeted therapies are limited. Jessica M. Keilson, MD, Winship Cancer Institute, Emory University, Atlanta, GA, and colleagues, in association with the Cholangiocarcinoma Foundation (CCF), conducted a patient-reported health-related QOL study to gain insight into the effect of physical, psychosocial, and financial challenges on patients with CCA. Dr Keilson presented the results at the 2022 ASCO GI Cancers Symposium.
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TOPAZ-1: Durvalumab plus Gemcitabine and Cisplatin in Advanced Biliary Tract Cancer
ASCO GI Highlights
March 2022, Vol 3, No 1
The global, double-blind, placebo-controlled, phase 3 TOPAZ-1 clinical trial evaluated the first-line chemoimmunotherapy regimen of the PD-L1 inhibitor durvalumab plus gemcitabine and cisplatin in patients with advanced biliary tract cancer. Do-Youn Oh, MD, PhD, Division of Medical Oncology, Department of Internal Medicine, Seoul National University Hospital, South Korea, presented the results of the planned interim analysis for this study at the 2022 ASCO GI Cancers Symposium.
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Derazantinib in Patients with Intrahepatic Cholangiocarcinoma and FGFR2 Mutations or Amplifications: The FIDES-01 Study
ASCO GI Highlights
March 2022, Vol 3, No 1
Derazantinib is a potent oral inhibitor of
FGFR1
,
FGFR2
, and
FGFR3
that is being investigated in the phase 2 FIDES-01 clinical trial of patients with advanced intrahepatic cholangiocarcinoma (CCA) harboring FGFR2 fusions or rearrangements.
Read More
Family History of Primary Liver Cancer Associated with Increased Risk for Extrahepatic CCA
ASCO GI Highlights
March 2022, Vol 3, No 1
The subtypes of cholangiocarcinoma (CCA), including intrahepatic CCA and extrahepatic CCA, have various underlying tumor microenvironments, pathobiology, epidemiologic features, and risk factors; however, the genetic underpinnings of the CCA subtypes have not been previously defined.
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Real-World Prevalence of Germline Mutations Associated with Homologous Recombination Deficiency in Patients with Biliary Tract Cancer
ASCO GI Highlights
March 2022, Vol 3, No 1
Mutations associated with homologous recombination deficiency (HRD) have been identified in up to 25% of patients with biliary tract cancers; however, the proportion of patients with germline versus somatic mutations has not been previously defined.
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Natural History of Patients with Advanced Cholangiocarcinoma and FGFR2 Fusion or Other Rearrangements
ASCO GI Highlights
March 2022, Vol 3, No 1
Real-world data are limited regarding the natural history of patients with advanced cholangiocarcinoma (CCA) and FGFR2 fusion or other rearrangements who are receiving therapies for advanced disease. Rachna T. Shroff, MD, of the University of Arizona Cancer Center, Tucson, and colleagues conducted a retrospective, observational natural history study to compare real-world overall survival (OS) in patients with advanced CCA and FGFR2 fusion or other rearrangements versus patients with wild-type FGFR2 from the diagnosis of advanced CCA to death. Dr Shroff presented the study results at the 2022 ASCO GI Cancers Symposium.
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Comparing Results with Futibatinib and Pemigatinib versus Chemotherapy in Patients with Cholangiocarcinoma and FGFR2 Fusion or Other Rearrangements
ASCO GI Highlights
March 2022, Vol 3, No 1
The phase 2 FOENIX-CCA2 clinical trial evaluated the investigational
FGFR1-4
inhibitor futibatinib in patients with advanced intrahepatic cholangiocarcinoma (CCA) harboring
FGFR2
fusion or other rearrangements.
Read More
Update on Emerging Systemic Therapies in Cholangiocarcinoma
CCF Highlights
March 2022, Vol 3, No 1
On the second day of the 2022 Cholangiocarcinoma Foundation annual meeting, Lipika Goyal, MD, MPhil, Assistant Professor of Medicine, Harvard Medical School, and Lead, Liver Cancer Research Program, Massachusetts General Hospital Cancer Center, Boston, presented a clinical update on emerging systemic therapies in cholangiocarcinoma (CCA).
Read More
The Cholangiocarcinoma Foundation’s Patient Advocacy Initiatives
CCF Corner
March 2022, Vol 3, No 1
At the 2022 Cholangiocarcinoma Foundation (CCF) Annual Conference on February 22-25, Melinda Bachini, Director of Advocacy of CCF, provided an update about the foundation’s advocacy and patient support initiatives. The goal of the CCF’s advocacy group is to provide educational and emotional support for the cholangiocarcinoma (CCA) community of patients and caregivers, and to empower them with the knowledge and guidance needed to self-advocate.
Read More
The International Cholangiocarcinoma Research Network Program Initiatives
CCF Highlights
March 2022, Vol 3, No 1
The International Cholangiocarcinoma Research Network (ICRN) is a program initiated by the Cholangiocarcinoma Foundation (CCF). The core mission of this network of international experts is “to rapidly translate scientific discoveries into practice for cholangiocarcinoma patients through a collaborative, highly translational international research network.”
Read More
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