The Lynx Group
Cholangiocarcinoma News

ASCO GI Highlights

March 2022, Vol 3, No 1 — March 29, 2022
The global, double-blind, placebo-controlled, phase 3 TOPAZ-1 clinical trial evaluated the first-line chemoimmunotherapy regimen of the PD-L1 inhibitor durvalumab plus gemcitabine and cisplatin in patients with advanced biliary tract cancer. Do-Youn Oh, MD, PhD, Division of Medical Oncology, Department of Internal Medicine, Seoul National University Hospital, South Korea, presented the results of the planned interim analysis for this study at the 2022 ASCO GI Cancers Symposium.
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March 2022, Vol 3, No 1 — March 29, 2022
The phase 2 FOENIX-CCA2 clinical trial evaluated the investigational FGFR1-4 inhibitor futibatinib in patients with advanced intrahepatic cholangiocarcinoma (CCA) harboring FGFR2 fusion or other rearrangements.
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March 2022, Vol 3, No 1 — March 29, 2022
Real-world data are limited regarding the natural history of patients with advanced cholangiocarcinoma (CCA) and FGFR2 fusion or other rearrangements who are receiving therapies for advanced disease. Rachna T. Shroff, MD, of the University of Arizona Cancer Center, Tucson, and colleagues conducted a retrospective, observational natural history study to compare real-world overall survival (OS) in patients with advanced CCA and FGFR2 fusion or other rearrangements versus patients with wild-type FGFR2 from the diagnosis of advanced CCA to death. Dr Shroff presented the study results at the 2022 ASCO GI Cancers Symposium.
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March 2022, Vol 3, No 1 — March 29, 2022
Mutations associated with homologous recombination deficiency (HRD) have been identified in up to 25% of patients with biliary tract cancers; however, the proportion of patients with germline versus somatic mutations has not been previously defined.
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March 2022, Vol 3, No 1 — March 29, 2022
The subtypes of cholangiocarcinoma (CCA), including intrahepatic CCA and extrahepatic CCA, have various underlying tumor microenvironments, pathobiology, epidemiologic features, and risk factors; however, the genetic underpinnings of the CCA subtypes have not been previously defined.
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March 2022, Vol 3, No 1 — March 29, 2022
Derazantinib is a potent oral inhibitor of FGFR1, FGFR2, and FGFR3 that is being investigated in the phase 2 FIDES-01 clinical trial of patients with advanced intrahepatic cholangiocarcinoma (CCA) harboring FGFR2 fusions or rearrangements.
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March 2022, Vol 3, No 1 — March 29, 2022
The ongoing open-label, multicenter, phase 2a LUC2001 study is investigating the efficacy and safety of the FGFR inhibitor erdafitinib in a molecularly defined subset of Asian patients with advanced cholangiocarcinoma (CCA) harboring FGFR alterations whose disease progressed after ≥1 previous systemic therapies.
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March 2022, Vol 3, No 1 — March 29, 2022
Data related to health-related quality of life (QOL), including financial toxicity, for patients with cholangiocarcinoma (CCA) who are receiving targeted therapies are limited. Jessica M. Keilson, MD, Winship Cancer Institute, Emory University, Atlanta, GA, and colleagues, in association with the Cholangiocarcinoma Foundation (CCF), conducted a patient-reported health-­related QOL study to gain insight into the effect of physical, psychosocial, and financial challenges on patients with CCA. Dr Keilson presented the results at the 2022 ASCO GI Cancers Symposium.
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March 2022, Vol 3, No 1 — March 29, 2022
Biliary tract cancers represent a heterogeneous group of tumors that includes intrahepatic cholangiocarcinoma (CCA), extrahepatic CCA, and gallbladder carcinoma. Teresa Macarulla, MD, PhD, Hospital Universitario Vall d’Hebron, Barcelona, Spain, and colleagues conducted a study to characterize the epidemiology of patients with biliary tract cancer, including patient management and survival outcomes. Dr Macarulla presented the results at the 2022 ASCO GI Cancers Symposium.
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March 2022, Vol 3, No 1 — March 29, 2022
Stereotactic body radiotherapy (SBRT) is increasingly being used for the treatment of patients with primary or metastatic liver cancer. A single-institution study was conducted to assess the incidence of central hepatobiliary adverse events (AEs) in patients with liver malignancies who were treated with SBRT, and to evaluate the relation with planned dosimetry to define predictors to minimize AEs. The results were presented by Nitika Thawani, Dignity Health Cancer Institute, Phoenix, AZ, at the 2022 ASCO GI Cancers Symposium.
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