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2021 Year in Review - Cholangiocarcinoma
2021 Year in Review: Cholangiocarcinoma
A Comprehensive Genomic and Immune Profiling Study of IDH1- and IDH2-Driven Intrahepatic CCA
Cholangiocarcinoma
2021 Year in Review: Cholangiocarcinoma
— December 17, 2021
A comprehensive genomic and immune characterization of
IDH
-mutated and wild-type intrahepatic CCA revealed significant differences in genetic alterations.
Read More
Tibsovo (Ivosidenib) FDA Approved for Advanced or Metastatic Cholangiocarcinoma and IDH1 Mutation
By
Loretta Fala
Cholangiocarcinoma
2021 Year in Review: Cholangiocarcinoma
— December 17, 2021
Cholangiocarcinoma (CCA) is an aggressive cancer of the bile duct that forms inside the liver (ie, intrahepatic) or outside the liver (ie, extrahepatic, including perihilar and distal tumors). Individuals with colitis or certain liver diseases may have an increased risk for CCA. Although the precise incidence of CCA is unknown, an estimated 8000 new cases of CCA are diagnosed annually in the United States. It is likely, however, that this number is higher, because CCA is difficult to diagnose and may be misclassified at times.
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Efficacy and Safety of Nab-Paclitaxel plus Gemcitabine/Cisplatin in Korean Patients with Advanced Biliary Tract Cancers
Biliary Tract Cancer
2021 Year in Review: Cholangiocarcinoma
— December 17, 2021
Real-world retrospective evidence from Korean patients with advanced biliary tract cancer indicates that efficacy and safety with nab-paclitaxel plus gemcitabine/cisplatin combination were consistent with those previously reported in clinical trials.
Read More
Comparative Landscape of Actionable Somatic Alterations in Advanced CCA from Circulating Tumor and Tissue-Based DNA Profiling
Cholangiocarcinoma
2021 Year in Review: Cholangiocarcinoma
— December 17, 2021
Findings from a retrospective analysis support the use of both tissue and liquid biopsy biomarker testing to guide therapy selection in patients with advanced CCA, particularly when tissue may not be readily available.
Read More
Role of ctDNA to Predict Risk for Recurrence Following Potentially Curative Resection of Biliary Tract and Pancreatic Malignancies
Biliary Tract Cancer
2021 Year in Review: Cholangiocarcinoma
— December 17, 2021
Results of a pilot study demonstrate the feasibility of ctDNA testing and the prognostic value of ctDNA following potentially curative resection in patients with pancreatic/biliary tract malignancies.
Read More
Does Adjuvant Chemoradiation Benefit Patients with Lymph Node–Positive Biliary Tract Cancer? A Secondary Analysis of SWOG S0809
Biliary Tract Cancer
2021 Year in Review: Cholangiocarcinoma
— December 17, 2021
Results of the secondary analysis of the SWOG S0809 trial indicate that nodal status did not impact survival outcomes achieved with adjuvant chemoradiation postresection in patients with extrahepatic CCA or gallbladder cancer.
Read More
Liposomal Irinotecan plus 5-Fluorouracil/Leucovorin or Gemcitabine/Cisplatin in Patients with Advanced Biliary Tract Cancer (NIFE Trial)
Biliary Tract Cancer
2021 Year in Review: Cholangiocarcinoma
— December 17, 2021
The phase 2 NIFE study compared a liposomal irinotecan plus fluorouracil and leucovorin regimen with standard-of-care gemcitabine/cisplatin in patients with advanced biliary tract cancer.
Read More
Liposomal Irinotecan in Combination with 5-Fluorouracil and Leucovorin for Patients with Metastatic Biliary Tract Cancer After Progression on Gemcitabine plus Cisplatin: A Multicenter, Comparative, Randomized, Phase 2b Study (NIFTY)
Biliary Tract Cancer
2021 Year in Review: Cholangiocarcinoma
— December 17, 2021
Results of the NIFTY trial demonstrated that liposomal irinotecan plus 5-fluorouracil and leucovorin significantly improved efficacy outcomes compared with 5-fluorouracil plus leucovorin alone in patients with biliary tract cancer who progressed on prior gemcitabine/cisplatin, with a manageable adverse event profile.
Read More
First-Line Toripalimab plus Lenvatinib in Combination with GemOx Chemotherapy for Advanced Intrahepatic CCA
Cholangiocarcinoma
2021 Year in Review: Cholangiocarcinoma
— December 17, 2021
Results of a phase 2 study indicate that toripalimab and lenvatinib in combination with GemOx chemotherapy provide antitumor activity and reasonable tolerability in patients with advanced intrahepatic CCA.
Read More
Phase 2a MyPathway Results of Pertuzumab plus Trastuzumab for the Treatment of HER2-Positive Metastatic Biliary Tract Cancer
Biliary Tract Cancer
2021 Year in Review: Cholangiocarcinoma
— December 17, 2021
Results of an ongoing, phase 2a, multiple-basket study (MyPathway) showed that dual
HER2
-targeted therapy with pertuzumab plus trastuzumab was well-tolerated in patients with previously treated
HER2
-positive metastatic biliary tract cancer.
Read More
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