2021 Year in Review: Cholangiocarcinoma

Mature results from a phase 2 study demonstrated that the FGFR inhibitor infigratinib has antitumor activity and a manageable adverse event profile in previously treated patients with locally advanced or metastatic CCA harboring FGFR2 gene fusions or rearrangements.
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Real-world evidence demonstrates a survival advantage for patients with CCA harboring FGFR2 fusions/rearrangements compared with those with FGFR2 wild-type CCA.
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