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2020 Year in Review - Cholangiocarcinoma
2020 Year in Review: Cholangiocarcinoma
Correlation of Next-Generation Sequencing and PCR Analysis of ctDNA with Clinical Outcomes and Emerging Mutations Linked to Drug Resistance
2020 Year in Review: Cholangiocarcinoma
— December 19, 2020
Preclinical data indicate that genetic analysis of ctDNA from patients with advanced CCA harboring IDH mutations was concordant with those of tissue samples and could detect emerging mutations associated with treatment resistance.
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Importance of PKN2 Signaling in the Development of Drug Resistance in Patients with CCA and FGFR2 Fusion
Cholangiocarcinoma
2020 Year in Review: Cholangiocarcinoma
— December 19, 2020
Preclinical evidence presented at the AACR meeting implicates PKN2 signaling in resistance mechanisms in patients with FGFR2 fusion–positive intrahepatic CCA.
Read More
Drug Sensitivities Are Predicted with Tumor Organoid-Based Functional Analysis in Patients with Cholangiocarcinoma
Cholangiocarcinoma
2020 Year in Review: Cholangiocarcinoma
— December 19, 2020
Patient-derived tumor organoids may have clinical application to predict drug responses in a personalized treatment setting; they have shown concordance with actionable genomic anchors and retrospective treatment outcomes.
Read More
Patient-Derived Organoids for Personalized Drug Screening in Intrahepatic CCA
Cholangiocarcinoma
2020 Year in Review: Cholangiocarcinoma
— December 19, 2020
Emerging data suggest that patient-derived 3-dimensional organoid model of intrahepatic CCA may allow personalized drug screening for active single agents or drug combinations similar to patient-derived xenograft models.
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Institutional Review Data Indicate That Actionable Genetic Testing and Personalized Medicine in Hepatobiliary and Pancreatic Cancers Is Rarely Applied
Cholangiocarcinoma
,
Pancreatic Cancer
2020 Year in Review: Cholangiocarcinoma
— December 19, 2020
Real-world data indicate that genetic testing and personalized medicine is rarely applied in the community setting for patients with hepatobiliary and pancreatic cancers.
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Comparison of the Clinical Features, Treatment Patterns, and Tumor Mutations of Patients with Intrahepatic and Extrahepatic CCA
Cholangiocarcinoma
2020 Year in Review: Cholangiocarcinoma
— December 19, 2020
Retrospective chart review data indicate that intrahepatic CCA and extrahepatic CCA exhibit disparate clinical features and molecular profile, and divergent treatment patterns.
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Primary versus Metastatic Intrahepatic CCA: A Comparative Comprehensive Genomic Profiling Study
2020 Year in Review: Cholangiocarcinoma
— December 19, 2020
Comprehensive genomic profiling data indicate that genetic profile of primary intrahepatic CCA was significantly different from metastatic intrahepatic CCA, with different rates of potentially targetable genetic alterations.
Read More
Toripalimab, Lenvatinib, plus Chemotherapy a Promising Combination in Advanced Unresectable Intrahepatic CCA
Cholangiocarcinoma
2020 Year in Review: Cholangiocarcinoma
— December 19, 2020
The multidrug combination of toripalimab, lenvatinib plus chemotherapy with gemcitabine and oxaliplatin showed promising efficacy and tolerability in patients with intrahepatic CCA.
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PROOF Trial: A Multicenter, Open-Label Randomized, Phase 3 Trial of Infigratinib versus Gemcitabine plus Cisplatin in Patients with Advanced CCA with FGFR2 Gene Rearrangements
Cholangiocarcinoma
2020 Year in Review: Cholangiocarcinoma
— December 18, 2020
The ongoing PROOF trial (NCT03773302) is evaluating the efficacy and safety of infigratinib versus gemcitabine plus cisplatin as frontline therapy in patients with advanced CCA harboring FGFR2 gene rearrangements.
Read More
The Worldwide Incidence of Biliary Tract Cancer
Biliary Tract Cancer
2020 Year in Review: Cholangiocarcinoma
— December 18, 2020
Assessment of global epidemiologic trends in incidence of biliary tract cancers (BTCs) showed higher BTC incidence in Asian versus Western countries as well as intraregional variations within countries, which is consistent with previous reports.
Read More
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