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Issues
2020
December 2020, Vol 1, No 3
December 2020, Vol 1, No 3
Targeted Therapies in Cholangiocarcinoma: Next-Generation Sequencing Is a Must
CCA Summit 2020 Highlights
,
Cholangiocarcinoma
December 2020, Vol 1, No 3
The recent FDA approval of the first
FGFR
inhibitor, pemigatinib (Pemazyre), and the positive results from the phase 3 study of the first
IDH1
inhibitor, ivosidenib (Tibsovo), represent major breakthroughs in the treatment of patients with cholangiocarcinoma (CCA), a rare cancer associated with poor outcomes. However, the duration of response with these agents is still relatively short.
Read More
Where There Is Hope
By
Laura R. Hnat
CCF Corner
December 2020, Vol 1, No 3
“You have cancer.” These are the 3 little words that everyone dreads hearing and that doctors wish they never had to utter. Yet according to the American Cancer Society, an estimated 1.8 million people will be diagnosed with cancer in the United States this year, and more than 600,000 people will die of it.
Read More
Gallbladder Cancer: Novel Approaches to Therapy Are Needed
CCA Summit 2020 Highlights
,
Gallbladder Cancer
December 2020, Vol 1, No 3
The current standard of care for the systemic treatment of patients with advanced gallbladder cancer is the chemotherapy combination of gemcitabine and cisplatin, which is suboptimal, yielding only modest benefit, said Richard Kim, MD, Section Chief, Gastrointestinal Medical Oncology, Moffitt Cancer Center, Tampa, FL, at the 2020 Cholangiocarcinoma Summit.
Read More
Takeaways from the 2020 Cholangiocarcinoma Summit
By
Milind M. Javle, MD
Letter from the Editor-in-Chief
December 2020, Vol 1, No 3
In this last issue for the year, we are highlighting the proceedings of the Second Annual Cholangiocarcinoma (CCA) Summit, which was conducted on October 22-23, 2020. This summit attracted a wide, multidisciplinary audience and was very interactive, despite being a virtual event. An important focus for this meeting was the emergence of molecular targets in CCA and early successes seen with precision medicine in this disease. Many of the key presentations from the summit are included in the current issue and are highlighted below.
Read More
FGFR Inhibition in Cholangiocarcinoma: Overcoming Acquired Resistance
CCA Summit 2020 Highlights
,
Cholangiocarcinoma
December 2020, Vol 1, No 3
In April 2020, the FDA granted accelerated approval to pemigatinib (Pemazyre), the first targeted therapy for cholangiocarcinoma (CCA). The
FGFR
inhibitor was approved for adults with CCA and
FGFR2
fusion.
Read More
Emerging Molecular Targets in Cholangiocarcinoma: IDH1, HER2, BRAF, and Beyond
CCA Summit 2020 Highlights
,
Cholangiocarcinoma
December 2020, Vol 1, No 3
Targeted therapy has improved survival for patients with cancer across a broad spectrum of disease sites, but until recently, progress has been slow in the treatment of patients with cholangiocarcinoma (CCA).
Read More
Improving Chemotherapy Combinations and Novel Treatments Are Needed in Advanced Biliary Tract Cancer
CCA Summit 2020 Highlights
December 2020, Vol 1, No 3
New cytotoxic chemotherapy regimens and novel combinations are being evaluated in clinical trials in an effort to improve the outcomes of chemotherapy in the adjuvant and palliative settings in patients with biliary tract cancer, including cholangiocarcinoma (CCA), said Angela Lamarca, MD, PhD, MSc, Consultant, Medical Oncology, the Christie NHS Foundation Trust, Manchester, United Kingdom. She discussed the future of cytotoxic chemotherapy for this patient population at the 2020 Cholangiocarcinoma Summit.
Read More
Role of Liver Transplant in Patients with Cholangiocarcinoma
CCA Summit 2020 Highlights
December 2020, Vol 1, No 3
Liver transplant is emerging as a treatment option in patients with unresectable hilar or intrahepatic cholangiocarcinoma (CCA), with accumulating data supporting transplant protocols in patients with early-stage CCA.
Read More
The Oncology Pipeline Offers Hope for Patients with Cholangiocarcinoma
CCA Summit 2020 Highlights
,
Cholangiocarcinoma
December 2020, Vol 1, No 3
Despite the onslaught of the COVID-19 pandemic, researchers are hard at work to develop innovative therapies that will make a difference in the lives of patients with cancer.
Read More
Genomic Testing in Cholangiocarcinoma: Look for Actionable Molecular Alterations
CCA Summit 2020 Highlights
,
Cholangiocarcinoma
December 2020, Vol 1, No 3
At the 2020 Cholangiocarcinoma Summit, Nabeel El-Bardeesy, PhD, Associate Professor, Medicine, Harvard Medical School, and Associate Geneticist, Center for Cancer Research, Massachusetts General Hospital Cancer Center, Boston, MA, moderated a session titled “Molecular Biomarkers in CCA: Focus on Current and Emerging Technologies.” The session focused on how best to integrate the array of genomic testing platforms into clinical practice. The session included 2 presenters who discussed this topic.
Read More
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