Using FGFR Inhibitors in Clinical Practice

Videos — May 14, 2020

Featuring:

Milind M. Javle, MD
Hubert L. and Olive Stringer Professor
Department of Gastrointestinal Medical Oncology
Division of Cancer Medicine
The University of Texas
M.D. Anderson Cancer Center
Houston, TX
Chair, NCI Task Force: Hepatobiliary Cancers
Angela Lamarca, MD, PhD, MSc
Consultant (FEA) in Medical Oncology
HPB-NET–Gastrointestinal Tumors Group, Department of Oncology
Fundación Jiménez Díaz University Hospital
Autonomous University of Madrid
Madrid, Spain
Vaibhav Sahai, MBBS, MS
Associate Professor
Section Head GI Oncology
Division of Hematology and Oncology
University of Michigan
Ann Arbor, MI

Dr Angela Lamarca discusses the use of FGFR inhibitors in daily practice. Their use will depend largely on data from currently ongoing second- and first-line clinical trials. She suggests that consideration should be given to their use in combination with chemotherapy and/or as maintenance therapy after first-line chemotherapy. Dr Milind Javle summarizes the field, suggesting that a time may come when patients with CCA are never treated with chemotherapy at all. Pemigatinib was FDA approved as second-line therapy in cholangiocarcinoma in May 2020.

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