Encourage Your Patients to Participate! Actively Recruiting US-Based  Clinical Trials in CCA

Encourage Your Patients to Participate! Actively Recruiting US-Based Clinical Trials in CCA

New Feature

June 2023, Vol 4, No 2

26 US-Based Clinical Trials of Note in CCA

That Are Active and Recruiting

Systemic Medical Therapy/Phase 2-3

Clinical trial recruitment and retention remain challenging in the quest to bring innovative medicines to patients. In oncology, therapies continue to evolve, yet researchers are frequently faced with low trial participation, particularly among minority groups.

This new CCA News feature aims to provide an ongoing list of US-based clinical trials that are actively recruiting for clinicians to use in discussions with their patients to encourage enrollment. The highlighted trials are new to this issue. Clinical trial identifiers can be found on www.ClinicalTrials.gov.

Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer/Biliary Tract Cancer: NCT05775159

Brightline-2: A Study to Test Whether BI 907828 Helps People With Cancer in the Biliary Tract, Pancreas, Lung or Bladder: NCT05512377

A Study to Evaluate Abemaciclib in Advanced Biliary Tract Carcinoma: NCT04003896

A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors (NAVIGATE): NCT02576431

mFOLFIRINOX Followed by Hepatic Arterial Infusion of Floxuridine and Dexamethasone With Systemic mFOLFIRI for Unresectable Liver-dominant Intrahepatic Cholangiocarcinoma: NCT04251715

M9241 in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer or Intrahepatic Cholangiocarcinoma: NCT05286814

Infigratinib for the Treatment of Advanced or Metastatic Solid Tumors in Patients With FGFR Gene Mutations: NCT04233567

Gemcitabine and Oxaliplatin Chemotherapy With or Without a Floxuridine and Dexamethasone Pump in People With Cholangiocarcinoma That Cannot Be Removed With Surgery: NCT04891289

XmAb20717 in Advanced Biliary Tract Cancers: NCT05297903
Study of the Combination of DKN-01 and Nivolumab in Previously Treated Patients with Advanced Biliary Tract Cancer (BTC): NCT04057365
Durvalumab (MEDI4736) and Tremelimumab and Radiation Therapy in Hepatocellular Carcinoma and Biliary Tract Cancer: NCT03482102
NAPOLI-2: Fluorouracil, Leucovorin, and Nanoliposomal Irinotecan in Biliary Cancer: NCT04005339
Olaparib in Treating Patients with Metastatic Biliary Tract Cancer with Aberrant DNA Repair Gene Mutations: NCT04042831
A Study of CTX-009 in Combination with Paclitaxel in Adult Patients with Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers: NCT05506943
Durvalumab and Tremelimumab with Platinum-Based Chemotherapy in Intrahepatic Cholangiocarcinoma: NCT04989218
SA Study to Evaluate the Efficacy and Safety of Pemigatinib versus Chemotherapy in Unresectable or Metastatic Cholangiocarcinoma (FIGHT-302): NCT03656536
Study to Evaluate the Efficacy and Safety of TT-00420 in Cholangiocarcinoma: NCT04919642
Pressure-Enabled Delivery of SD-101 with Checkpoint Blockade for Primary Liver Tumors: NCT05220722
Olaparib in Treating Patients with Advanced Glioma, Cholangiocarcinoma, or Solid Tumors with IDH1 or IDH2 Mutations: NCT03212274
REFOCUS: A First-in-Human Study of Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients with ICC and Other Advanced Solid Tumors: NCT04526106
Study of Olaparib and Durvalumab in IDH-Mutated Solid Tumors: NCT03991832
LYT-200 Alone and in Combination with Chemotherapy or Anti-PD-1 in Patients with Metastatic Solid Tumors: NCT04666688
Gemcitabine and Cisplatin with or without CPI-613 as First Line Therapy for Patients with Advanced Unresectable Biliary Tract Cancer (BilT-04): NCT04203160
Atezolizumab plus Tivozanib in Immunologically Cold Tumor Types: NCT05000294
Study of TT-00420 Tablet as Monotherapy and Combination Therapy in Patients with Advanced Solid Tumors: NCT04742959
A Safety and Efficacy Study of ZW25 (Zanidatamab) plus Combination Chemotherapy in HER2-expressing Gastrointestinal Cancers, Including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer, and Colorectal Cancer: NCT03929666

Encourage Your Patients to Participate! Actively Recruiting US-Based Clinical Trials in CCA

26 US-Based Clinical Trials of Note in CCA

That Are Active and Recruiting

Systemic Medical Therapy/Phase 2-3

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Encourage Your Patients to Participate! Actively Recruiting US-Based Clinical Trials in CCA

26 US-Based Clinical Trials of Note in CCA

That Are Active and Recruiting

Systemic Medical Therapy/Phase 2-3

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