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Web Exclusives
Efficacy and Safety of Infigratinib in Patients with Previously Treated Advanced CCA with an FGFR2 Gene Fusion or Rearrangement
Monthly Minutes
Web Exclusives
— December 20, 2021
Infigratinib demonstrates significant efficacy and a manageable safety profile in patients with previously treated, locally advanced or metastatic CCA with an
FGFR2
gene fusion or rearrangement.
Read More
Efficacy and Safety of Ivosidenib in Patients with Previously Treated CCA with an IDH1 Mutation: The ClarIDHy Trial
Monthly Minutes
Web Exclusives
— December 20, 2021
The ClarIDHy trial demonstrated safety and efficacy of ivosidenib in patients with previously treated metastatic CCA harboring an
IDH1
mutation.
Read More
Futibatinib in iCCA with FGFR2 Fusions/Rearrangements: The FOENIX-CCA2 Study
Monthly Minutes
Web Exclusives
— December 20, 2021
Initial results of the phase 2 FOENIX-CCA2 study demonstrated that futibatinib demonstrated efficacy and a manageable safety profile in patients with previously treated iCCA harboring an
FGFR2
fusion or rearrangement.
Read More
Efficacy and Safety of Derazantinib in Patients with Previously Treated iCCA with an FGFR2 Fusion or Rearrangement: The FIDES-01 Study
Monthly Minutes
Web Exclusives
— December 20, 2021
The phase 2 FIDES-01 study demonstrated that derazantinib resulted in objective responses and a manageable safety profile in patients with previously treated iCCA with an FGFR2 fusion or rearrangement.
Read More
Safety and Initial Efficacy of Zanidatamab (ZW25) in HER2-Overexpressing Biliary Tract Cancer
Monthly Minutes
Web Exclusives
— December 20, 2021
Results from a phase 1 study showed that the bispecific
HER2
-targeted antibody zanidatamab is well-tolerated and demonstrates clinical activity in patients with
HER2
-overexpressing biliary tract cancer.
Read More
Comparison of Liposomal Irinotecan (nal-IRI) plus 5-Fluorouracil/Leucovorin (5-FU/LV) versus Gemcitabine/Cisplatin as First-Line Therapy in Patients with Advanced Biliary Tract Cancer: The NIFE Trial
Monthly Minutes
Web Exclusives
— December 20, 2021
The NIFE study demonstrated the efficacy and safety of the nal-IRI-plus-5-FU/LV regimen as first-line therapy in patients with advanced biliary tract cancer, with a clear benefit over gemcitabine/cisplatin in extrahepatic cholangiocarcinoma.
Read More
FDA Grants TT-00420, a Multi-Kinase Inhibitor, Fast-Track Review for Cholangiocarcinoma
FDA Approvals, News & Updates
,
Cholangiocarcinoma
Web Exclusives
— November 9, 2021
On November 3, 2021, TransThera Sciences announced that the FDA granted its investigational drug, TT-00420, a spectrum-selective multi-kinase inhibitor, a fast-track designation for the treatment of patients with cholangiocarcinoma (CCA) who have no available standard treatment options. In preclinical studies, TT-00420 has shown high activity in a variety of
FGFR
mutations.
Read More
First-Line Immunotherapy plus Chemotherapy Significantly Improves Survival in Advanced Biliary Tract Cancer
Biliary Tract Cancer
Web Exclusives
— October 28, 2021
On October 25, 2021, AstraZeneca announced high-level positive results from the phase 3 clinical trial TOPAZ-1, demonstrating that adding the immunotherapy durvalumab (Imfinzi) to first-line standard-of-care chemotherapy leads to a statistically significant and clinically meaningful overall survival (OS) benefit versus chemotherapy alone in patients with advanced biliary tract cancer.
Read More
Ivosidenib Approved for Advanced or Metastatic Cholangiocarcinoma
Cholangiocarcinoma
,
FDA Approvals, News & Updates
Web Exclusives
— August 30, 2021
Ivosidenib has been approved by the FDA for adult patients with previously treated, locally advanced or metastatic cholangiocarcinoma with an isocitrate dehydrogenase-1 mutation as detected by an FDA-approved test.
Read More
Amplity Health Designated “Trusted Partner” of Cholangiocarcinoma Foundation
Press Releases
Web Exclusives
— February 3, 2021
February 1, 2021 (Cranbury, NJ):
The Cholangiocarcinoma Foundation (CCF) designated Amplity Health as a “Trusted Partner,” 1 of only 4 organizations globally. A CCF “Trusted Partner” shares the CCF mission:
to find a cure and improve the quality of life for those affected by cholangiocarcinoma (CCA)
. These 4 esteemed partners are fundamental to the Foundation’s growth and ability to provide high-quality programs and services to the CCA community.
Read More
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