Web Exclusives

Web Exclusives — December 20, 2021
Infigratinib demonstrates significant efficacy and a manageable safety profile in patients with previously treated, locally advanced or metastatic CCA with an FGFR2 gene fusion or rearrangement.
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Web Exclusives — December 20, 2021
The ClarIDHy trial demonstrated safety and efficacy of ivosidenib in patients with previously treated metastatic CCA harboring an IDH1 mutation.
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Web Exclusives — December 20, 2021
Initial results of the phase 2 FOENIX-CCA2 study demonstrated that futibatinib demonstrated efficacy and a manageable safety profile in patients with previously treated iCCA harboring an FGFR2 fusion or rearrangement.
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Web Exclusives — December 20, 2021
The phase 2 FIDES-01 study demonstrated that derazantinib resulted in objective responses and a manageable safety profile in patients with previously treated iCCA with an FGFR2 fusion or rearrangement.
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Web Exclusives — December 20, 2021
Results from a phase 1 study showed that the bispecific HER2-targeted antibody zanidatamab is well-tolerated and demonstrates clinical activity in patients with HER2-overexpressing biliary tract cancer.
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Web Exclusives — December 20, 2021
The NIFE study demonstrated the efficacy and safety of the nal-IRI-plus-5-FU/LV regimen as first-line therapy in patients with advanced biliary tract cancer, with a clear benefit over gemcitabine/cisplatin in extrahepatic cholangiocarcinoma.
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Web Exclusives — November 9, 2021
On November 3, 2021, TransThera Sciences announced that the FDA granted its investigational drug, TT-00420, a spectrum-selective multi-kinase inhibitor, a fast-track designation for the treatment of patients with cholangiocarcinoma (CCA) who have no available standard treatment options. In preclinical studies, TT-00420 has shown high activity in a variety of FGFR mutations.
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Web Exclusives — October 28, 2021
On October 25, 2021, AstraZeneca announced high-level positive results from the phase 3 clinical trial TOPAZ-1, demonstrating that adding the immunotherapy durvalumab (Imfinzi) to first-line standard-of-care chemotherapy leads to a statistically significant and clinically meaningful overall survival (OS) benefit versus chemotherapy alone in patients with advanced biliary tract cancer.
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Web Exclusives — August 30, 2021
Ivosidenib has been approved by the FDA for adult patients with previously treated, locally advanced or metastatic cholangiocarcinoma with an isocitrate dehydrogenase-1 mutation as detected by an FDA-approved test.
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Web Exclusives — February 3, 2021
February 1, 2021 (Cranbury, NJ): The Cholangiocarcinoma Foundation (CCF) designated Amplity Health as a “Trusted Partner,” 1 of only 4 organizations globally. A CCF “Trusted Partner” shares the CCF mission: to find a cure and improve the quality of life for those affected by cholangiocarcinoma (CCA). These 4 esteemed partners are fundamental to the Foundation’s growth and ability to provide high-quality programs and services to the CCA community.
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