Considering Toxicities Associated with Specific and Pan-FGFR Inhibitors

Videos — April 21, 2021

Featuring:

Jesús Bañales, PhD
Biodonostia Institute
Pamplona, Spain
Antoine Hollebecque, MD
Gustave Roussy Cancer Center
Paris, France
Milind M. Javle, MD
Hubert L. and Olive Stringer Professor
Department of Gastrointestinal Medical Oncology
Division of Cancer Medicine
The University of Texas
M.D. Anderson Cancer Center
Houston, TX
Chair, NCI Task Force: Hepatobiliary Cancers
Angela Lamarca, MD, PhD, MSc
Consultant (FEA) in Medical Oncology
HPB-NET–Gastrointestinal Tumors Group, Department of Oncology
Fundación Jiménez Díaz University Hospital
Autonomous University of Madrid
Madrid, Spain
Drs Javle, Báñales, and Hollebecque describe their thoughts about the use of pan-FGFR inhibitors compared with those that primarily target FGFR2 and the potential of treating CCA with inhibitors of FGFR1, 3, and 4. Moreover, they consider the most common adverse events associated with inhibitors of FGFR2, of which the most difficult to manage are hyperphosphatemia, nail toxicity, eye toxicity, and fatigue. The importance of educating oncologists on how to treat these toxicities is key to maintaining dose intensity of FGFR inhibitors.

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