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FGFR2 Fusion and/or Rearrangement Profiling in Chinese Patients with Intrahepatic CCA

2021 Year in Review: Cholangiocarcinoma — December 17, 2021

Epidemiologic data assessed the incidence rate of FGFR2 gene fusion or rearrangement in Chinese patients with intrahepatic CCA, including those with heterogeneous FGFR2 partner genes.

The epidemiology of FGFR2 fusions/rearrangements in patients with intrahepatic cholangiocarcinoma (iCCA) in the Chinese population has not been defined. Findings from an observational study (ClinicalTrials.gov Identifier: NCT04256980) that evaluated the incidence of FGFR2 fusions/rearrangements in Chinese patients with iCCA were reported at the 2021 European Society for Medical Oncology Annual Congress.

At data cutoff (October 31, 2020), the study included a total of 728 samples from 728 adult patients with pathologically confirmed iCCA. All samples were tested for FGFR2 fusion or rearrangement; FGFR2 partner genes were assessed in 30 samples with known FGFR2 fusion or rearrangement.

Of the 717 samples that had readout, 6.14% were positive for FGFR2 gene fusion or rearrangement. The incidence rate varied by region, with the highest positive rate (10.5%) found in Southwest China and the lowest positive rate in South China (5%). In the 30 samples tested, a total of 26 different FGFR2 fusion partner genes were identified, 22 (84.6%) of which were unique to individual patients. The most common partner was FGFR2-WAC, which was observed in 10% of the samples.

Findings from this observational study indicate that the incidence rate of FGFR2 gene fusion or rearrangement in Chinese patients with iCCA was 6.14%, which is lower than the rate reported in the global population. The FGFR2 partner genes identified were highly heterogeneous in the Chinese population.

Source: Huang X, Shi G, Zhang T, et al. FGFR2 fusion and/or rearrangement profiling in Chinese patients with intrahepatic cholangiocarcinoma. Ann Oncol. 2021;32(suppl_5):S376-S381.

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