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Cholangiocarcinoma
Tucatinib and Trastuzumab in Patients With Previously Treated HER2-Positive Metastatic BTC: The SGNTUC-019 Study
Cholangiocarcinoma
This phase 2 basket study investigated the combination of tucatinib and trastuzumab as second-line treatment for patients with HER2-positive biliary tract cancer.
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Phase 2 BilT-02 Trial: Rucaparib and Nivolumab as Maintenance Therapy Following Chemotherapy in Patients With Advanced BTC
Cholangiocarcinoma
To improve survival in patients with biliary tract cancer, researchers are studying combinations of immunotherapy and poly-ADP ribose polymerase inhibitors; the BilT-02 study is summarized.
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Results From the Phase 2b HERIZON-BTC-01 Study of Zanidatamab in Previously Treated HER2-Amplified BTC
Cholangiocarcinoma
Researchers present preliminary findings from the HERIZON-BTC-01 study, which investigated zanidatamab’s efficacy in patients with HER2-positive biliary tract cancer.
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Using ctDNA as a Predictive Biomarker in Patients With CCA Before and During Chemotherapy: Subanalysis of the Phase 2 STAMP Trial
Cholangiocarcinoma
In a subanalysis of the STAMP trial, circulating tumor DNA was assessed for its clinical effectiveness in detecting molecular residual disease in patients with cholangiocarcinoma.
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Investigating Alterations in Cancer Driver Genes and Other Mutations in Patients With Intrahepatic CCA: Phase 3 BILCAP Trial
Cholangiocarcinoma
In patients with biliary tract cancer, EGFR amplifications and FGFR3 fusions may serve as important predictive biomarkers and as potential targets for anticancer therapy in the future.
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Using Liquid Biopsy to Detect FGFR2 and Other Actionable Rearrangements in GI Malignancies
Cholangiocarcinoma
An analysis of circulating tumor DNA–based comprehensive genomic profiling to detect actionable rearrangements in patients with gastrointestinal malignancies was presented by Pashtoon Kasi, MD, MS.
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BI 907828, an MDM2-p53 Antagonist, Demonstrated Promising Efficacy in Patients With Advanced BTC
Cholangiocarcinoma
Two phase 1a/1b dose-escalation/expansion trials investigated the efficacy and safety of MDM2-p53 antagonist BI 907828 in patients with advanced biliary tract cancer.
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Patients With Advanced BTC Treated With CTX-009 Plus Paclitaxel in a Phase 2 Study
Cholangiocarcinoma
CTX-009 in combination with paclitaxel showed encouraging efficacy in patients with advanced biliary tract cancer.
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The Use of Gunagratinib in Patients With Previously Treated Advanced CCA Harboring FGFR2 Fusions or Rearrangements: A Phase 2 Study
Cholangiocarcinoma
Gunagratinib is being investigated in an ongoing phase 2a dose-expansion study in patients with cholangiocarcinoma.
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GemCis and Nab-Paclitaxel Versus GemCis in Advanced BTC: Results From the SWOG 1815 Study
Cholangiocarcinoma
Results of the SWOG 1815 study failed to demonstrate a benefit with the addition of nab-paclitaxel to gemcitabine/cisplatin (GemCis) versus GemCis alone.
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